Upload & Sell: Off
I usually shoot 7D RAW at ISO 160, 320, 640 and 1250 and process them to 16-bit TIFFs in Aperture 3. I find these ISO settings cleaner than 200, 400, 800 and 1600. Although people even whine about noise at ISO 100-200 I find 160 really doesn't need NR if exposed to the right and pulled down prior to conversion. Obviously you can't use this technique on every photo--some have too much dynamic range--but I do it when I can. I leave Aperture sharpening low or off as I prefer to sharpen selectively and optimize for file size (different for web galleries vs large prints) as my final "save as" step in PS.
Of course all of Canon's auto illumination and HL modes should be disabled if noise control is important.
I find the de-noise, radius and moire sliders in Aperture 3 work great up ISO 640. However if a high ISO image contains a lot of skies or lower mids I get better results using Topaz Denoise 5 in a separate PS layer. I like being able to apply differing amounts of NR to shadows, skies or color channels without touching the well exposed subject. Also, I prefer not to pull up shadows too much as, besides accentuating patterned noise, it just looks unnatural to compress shadows, mids and highs into a narrow range. Hate the quasi HDR look.
Topaz Denoise on sky (ISO 800). The sky was really noisy and needed heavy NR. Should have used ISO 640 but I didn't know any better at the time.