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One thing to consider is selective sharpening. IMHO, you do not want to sharpen objects in the photo that either suffer with extra sharpening (like a woman's complexion, perhaps), or objects that were never meant to be sharpened in the first place (such as out of focus regions, or sky, or homogenous tones, etc.). If you sharpen the latter areas, you just magnify noise and artifact. By selectively sharpening, the sharp regions will appear even more sharp in contrast to the softer areas of the photo. In Lightroom, use the adjustment brush, and in Photoshop, consider layers with masking. I think if you have a large depth of field landscape, like Denoir's example, then stronger use of ACR's capabilities are nearly sufficient, as the newer versions essentially incorporate what people used to do in LAB mode, only much more easily and without conversions of modes, that would have introduced artifact, etc., fractionally with each conversion. So if only a smidgeon of the photo is meant to be in crisp focus, why sharpen at all with the global sliders?
With jpegs, I still use the old LAB mode of sharpening the lightness channel, with both high amount low radius, and low amount, high radius, fading the opacity a bit for each. And then I mask my sharpening as needed.