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Large tablets are for large drawing movements--stroking from the elbow or shoulder. Smaller tablets are for writing-like movements from the fingers or wrist.
I'm using only the touchpad on my laptop which is only 1-1/2" x 2-1/4" and my "wear" area is only about 1" ... i.e. finger movement only. My Gear Acquisition Syndrome makes me want to get a large tablet ... but the thought of using drawing movements (which I suck at and thus use a camera) keeps me from chunking down the $$$ for a large tablet.
I've always been of the physiological opinion that smaller muscles yield greater refined control, whereas larger ones make for more power/speed. Of course, the human body is highly adaptable and while I'd have never thought I'd be content with such a small area (GAS, etc.), I seem to have adapted to it very well ... in concert with RDKirk's position that press being received that larger is better, might be somewhat application biased.
I wouldn't suggest that someone aspire to use a 1" touchpad as I do, but I do think that RDKirk's point at which movement (fingertip, hand, wrist, arm, shoulder) you prefer is something for ergonomic consideration relative to your size choice. Like RDKirk ... I just zoom the screen, while my movements remain very consistent and only utilize small muscles.
I've never been comfortable using a pen or pencil except in very short strokes, i.e. I print or type vs. write, etc. I'd think that if a person has elegant penmanship (i.e. well developed movement control over larger areas) or drawing proficiency ... they may readily adapt to the larger tablet. For those of us that are "movement challenged" above the wrist, adapting to a large tablet might be a bit more arduous of a task.
Of course, all hand-eye coordination / muscle memory is a product of repetition and reinforcement ... as we are incredibly adaptable.