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Excuse for those that hate boring comparisons/tests, but I would like to share this one showing a simple comparison of one shot at f/16 vs. 3 shots focus stacked at f/8.
If you need the whole flower in focus, but no distracting background, focus stacking can be a solution.
Single shot vs. 3 focus stacked shots by labecoaves, on Flickr
D7000 + PN-11 tube + Nikkor 300mm f/4.5 AI-S EDIF + tripod. ISO 160, 1 single shot at f/15 1/50s; 3 shots at f/8 1/250s. Of course this will need still subjects. The flower had just 1cm diameter.