Among the presets are a number marked raw (which I understand are to be used on TIFs). How would you use the plug-in with raw files?
Apparently there is a finite size limit, Tried to do an older pano but couldn't. Is the limit dependent on the computer, or is it fixed? If it changes, what changes it?
With Photoshop and Topaz you can create an action, then you can identically process multiple files before stitching. Seems to work with all of the Topaz plug-ins.
Or, if you don't want to re-do your currrent pano, it's easy enough to split your current file into two or more files, process them and then reconnect them after. I've had to do that a few times with Noise Ninja on huge files. Not a big deal.
Apparently DeNoise is a bit more limited regarding image size than some other noise reduction packages but the actual limit depends on a number of factors including the configuration of your PC and whether you are using the 32 or 64 bit version of DeNoise.
Regarding your question about the raw presets, there is no way to use DeNoise directly on raw files. They must be converted to RGB files (TIF or PSD probably) and DeNoised in Photoshop. The reason that they name some of the presets with "Raw" is because those presets have been "tuned" to work best with images that started out as raw files. Noise characteristics for an image can be different depending on whether the source was Raw, Jpeg, or film.