I switch things up all the time on different trips. For instance, we just got home from a week in Hawaii. I brought a small, manual focus 35/1.4 (which I used about 70% of the time), a very small 14/4, 21/1.4, 75/2, and the big Sony 70-200 GM II. The zoom got used once on a whale watching tour (the only reason I brought it). I carried one to three lenses in my sling bag everywhere we went, usually taking the 35/1.4, 14mm, and 75mm.
Other trips I’ll take a 14mm, 24-70/2.8, and the 70-200/2.8, using the 24-70 90% of the time.
I don’t mind carrying gear on big vacations because I get most of my most satisfying images while on vacation with family. The weight and inconvenience is a small price to pay (in my opinion) for superb images of people and places I may only see once.