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As someone who is regularly in -25C to -35C, and much colder with windchill, nothing is going to prevent frostbite except dressing appropriately and properly covering up your skin.
There are creams that under certain circumstances can mitigate cellular damage from the effects frostbite, but not to a degree that is practical or worth bothering with, in my opinion anyway. Just cover up either with a full face balaclava/ski mask or wrap of some kind
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