Made the switch from a Elan 7E so there was not much of a learning curve BUT......
The exposure latitude is much smaller than film so it took a couple hundred pics to get the hang of it (they are free pics so it cost nothing but I lost a bunck of shots...).
I thought a 28 mm would be wide enough as I did not use it much when I had the Elan but I will have to get a wider lens.
Otherwise, construction, images, handling is all top notch.
Was also looking at the D100 but was not as happy with the images. The D100 seemed to have better flexibility but now that I'm used to the 10D's handling, it has not been a problem.
I have the 28 - 135 lens which is very versatile (aside from not being quite wide enough).
Would I buy it again? Absolutely!