I have had this case for more than a year now and it has served me well. I'm able to carry the following with this case: Canon 20D with BG-E2 Grip, 400mm 5.6L, 1.4x teleconverter, Kenko extension tube set, 50mm f/1.8, 550EX Flash, 18-55mm EF-S, cleaning equipment, filters, and a whole lot more.
Even with all of my equipment loaded it is comfortable to carry around for hours. The only thing that might be a problem for some people is the tripod/monopod holder. Honestly I think it is useless but this isn't a problem for me as I carry my tripod over my shoulder.