Just about the perfect size and weight for my day trip needs. Easily holds all the gear I want to carry at one time. Currently holding the following - 20D with BG E2, 70-200 f2.8 IS, 60mm Macro, 18-55 zoom, 1.4 extender, 580ex speedlight, battrery charger, tripod mounting bracket, filters, extra battery & memory cards, 2 hoods, instruction booklets, eyeglass case, and 2 bags of snacks. Still have room for the 17-40L or 24-70L I hope to add soon.
Love the fact that the center section holds camera with 70-200 f2.8 mounted and 18-55 or 60 Macro stowed below, or with simple movement of one divider can store camera with shorter lens attached, and 70-200 in space below. This allows me to quickly stow the camera without removing whichever lens I happen to be using.
Found I can conveniently tuck unneeded straps into velcroed compartments, but it would be a nice touch if they were removable.
I'v been using Lowepro bags for 25 yrs or so. This is the best of a good lot.