My only issue is that the case has a large hump in the middle (where the extension for pushing/pulling it around retracts) that can make carrying a Canon 2.8 a pain. I have removed the divider on one side so that the monopod mount flattens out more efficiently - but this has meant having to make sure the gear that used to be protected by the divider now gets protected by either padded camera straps or other dividers (depending on my mood). All in all, it's an effective work around.
As for the positives...you can put the Canon 400 2.8, 70-200 2.8, 24-70 2.8 and two bodies in it comfortably, as well as accessories. It will also hold your computer, but in order to get it into SW Air overheads I have to remove the computer.
It's very sturdy - I've had mine for four seasons of football, traveled up and down the west coast and while it shows some wear and tear, it's still a great piece of luggage. It's also been a godsend to have those backpack straps when we have to hike through a non-paved parking lot. It's comfortable on the back.
I've never used the rain cover and wish I could remove it without having to tear it out - but that's a minor issue.