John Wheeler Offline Upload & Sell: Off
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Hi stompya
There may be something behind your question based on your observation or experience that made you bring this question to the forum. If so, it might help to understand that background.
First I will limit my answer to the negative scan because 12 bit camera files are raw files which is different ballgame.
In general and practically, for most images you should not see changes in tonality assuming that you are referring to the range of highlights to shadows in the image.
However, academically, if you have very high frequency components that were also very high contrast in your image, you can have a shift in tonality. If the limit, I could create a b&W checkerboard pattern at the pixel level, then reduce the size of the image by 50%, and with most rendering algorithms, it would turn the image from all balck and white to solid gray.
Hard to answer your question with much more detail without more background of your questioni and also yrou own definition of tonality.
Hope this helps some
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