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It depends on what you are trying to achieve. There's hardly anything absolute in lens decision, only the compromise(s) taken.
The sharpest 50-ish lens on market is the Leica 50mm APO. It beats even the mighty Otus @F2.0, but again, it's only F2... so if you are looking for anything faster plus the fact that not everyone is ready to drop almost 9k on a standard lens, Otus is your friend.
If you want speed, Mitakon/Leica/Canon all offer lenses at F0.95 and it's very hard ($$$ and availability) to get anything faster on FF as far as I'm aware. AF is possible on the Leica via TAP. Or another AF option would be the Canon 50mm F1.0L again via Techart EF-NEX adapter.
If you want rendering, Nikon Noct, Zeiss Biotar, Konica Hexanon 60mm all offer very distinctive renderings, so take your pick. while AF is available via TAP on all 3.
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