garyvot Offline Upload & Sell: On
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Canon's APS-C sensor has only about 38.5% of the surface area of a full frame sensor, so it seems to me that yes, you do lose a percentage of the potential resolving power of a lens designed for a larger format. You are, in effect, throwing away 60% of the image circle, and also magnifying any lens aberrations.
Beyond focus issues, I think this accounts for the differing experiences that users report using certain older prime lenses, which can look okay on full frame but fall apart on smaller sensors.
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