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Yu won't notice any difference between USB3, TB, TB2, SATAII and SATAIII - no matter whether internal or external. 80% of the I/O is happening at under 100 MB/s and 99% of your I/O is happening at under 200 MB/s which all these interfaces support. There will be a slight difference in "iops" but nothing humanly detectable under normal use. You /might/ notice the iops difference if you were hosting massive databases to multiple users simultaneously but otherwise no. For MB/s you might notice a slight difference between these interfaces if/when you edit multiple layered streams of 1080p/50 or 4k streams but otherwise again, no.
It's not major surgery to add an SSD or even to replace your HDD boot-drive with an SSD. So considering all these things feel free to set it up however you like. Normally the only reason to use a TB or TB2 connection to storage is if your storage is a RAID 0 array. 8 HDDs or 3 SSDs might like to be on a TB connection if external. But if your running the SSD RAID 0 array where each drive is connected to it's own SATA internally that will be just fine too. The reason SSDs are so much faster than HDDs isn't because their top speeds are so much greater but because their low-end is so much higher. So for example, a typical HDD does about 1 to 4 MB/s when reading files of 16K and smaller - which most files are. But an SSD does 20 to 40 MB/s when reading 16k files - and that's a ten to twenty fold increase (literally 10 to 20 times faster). When reading 0.5k to 4k files the SSD is more 50 to 200 times faster and we all go: "WOW!". Still notice however that we're talking speeds supported by just about all common interfaces - even USB2.0. In contrast the top end on a modern HDD is about 200 MB/s while an SSD is only about 400 MB/s - which is only two times. I've extensively tested all these theories (except TB2) on both OS X and Windows even the USB2.0 I mentioned, so these aren't guesses.
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