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do you want to have a lens attached to the camera whilst it's in the bag? for years i searched for a bag/backpack that could take 1-series bodies with a lens attached, and the only ones that could (eg. lowepro vertex 200) weighed a ton.
this was an endless source of frustration for me until i came to the conclusion that i either had the camera with lens attached out and ready to shoot, or if it was going in the bag, the lens could come off. i then bought the think tank photo 'shapeshifter', and it has been fantastic!
i can fit 2 x 1-series bodies, a 70-210, and 2-3 other lenses, filters etc and still not have to use the 'expanding' feature, which makes it a very slim, low profile backpack. if you need to carry more gear, you simply undo one zipper and it swallows a whole lot more. and it's really light!