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What the h-- is ISS ??
Not very sure, but I guess it means Impossibly Small Subject.
I always have a tough time focusing on it, so I cheat by prefocusing on the moon, which is a much larger and slower target.
Here's how the moon looks this morning from our islands.
Canon 7D + 400 2.8 L IS + stacked Canon 2x and Sigma 2x TCs,
1600 mm, f/16, ISO 200, 1/30 sec, 475B/516 support.