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Sure. I don't use an F-stop ICU - I have a product like THIS for each of my lenses and body. I only brought my 14-24 and 24-70mm lenses with me, so I put each lens in its case, wrapped up my body in a similar case, and put them inside of this drybag. Then, I put the dry bag inside of my technical hiking pack, and hiked as I would if there were no water at all. My bag got wet, but I felt like that method was a good compromise between convenience and keeping my gear safe. I don't know what the water flow is now, but it was high last year, and the water was only deep enough to submerge part of my bag twice.
Look around, and you can find a dry bag that is the right size for your ICU. I believe all of the outfitters in Zion rent them as well. Good luck!