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I shoot with a 5D Mark III - I mostly use single point with AF point expansion, choose whichever AF point necessary to frame the subject the way I want, and use back button focusing. I usually use one-shot mode, but for moving subjects (aisle walks, dancing, etc), I use AI Servo. And I have the DoF preview button programmed to be the quick One-Shot->AI Servo switch.
When I used a 5D Mark II, I usually used just the center AF point and one-shot mode - focused on the subject, recomposed the shot, and shoot. I found the outer AF points and Servo mode to be unreliable on the Mark II.