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When holding the camera normally, my thumb is now resting on top of some buttons located in that area of the grip.
I assume you mean the live view/movie and AF-ON buttons. It was the very first thing I noticed about the camera on seeing pictures of it, and it's disappointing that at least some have found it to be a real problem. Does it affect the stability of your grip with long lenses? Are you accidentally operating the buttons?
But I have to say that the old location of AF-ON, on the shoulder rather than a flat part, means I operate it with the side of my thumb, and if I do that enough the quick gets sore. Whoever designs these things must have very short thumbs.
Yes, those are the buttons. Mind you, I haven't operated inadvertently any of them yet, and I have AF left on the main shutter release button, it is just a bit disconcerting to be feeling some buttons in the grip, however, I am sure I will stop noticing it in due course, it's just a matter of getting used to some newness.
What is interesting is that with 7D I do not have any issues with the pushbutton location.
However, I suppose when picking up large form 1DX, I automatically expect the same interface as 1DMkIIN/1DsMkII which I have used for years. For example, when wanting to change ISO, I am still reaching with two fingers of my left hand to those two pushbuttons on the left top panel of the camera......well, those ain't working on 1DX that way, there is a separate ISO pushbutton on the right top panel now.