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Personally I'd never say that YouTube tutorials are the "best approach."
Adobe makes an excellent Lightroom 4 User Guide available for free and my advice would be to read and absorb it. The User Guide has everything you need to know to master the program: http://help.adobe.com/en_US/lightroom/using/lightroom_4_help.pdf
Besides tutorials on U Tube, what is the best approach to learn LR4 for someone who never used LR...
thx for your time.