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Macaroni is a tried and trusted program for OSX maintenance. MacKeeper appears to be a risky venture...
Macaroni will run the daily, weekly, and monthly UNIX maintenance scripts. It will also rebuild disk permissions. Basically, Macaroni is a timer utility for setting the frequency of these maintenance operations. Macaroni is also a 32 bit preference panel; Apple may break it some day. Updates to Macaroni have been infrequent; basically it doesn't need frequent updates because of its limited actions.
Onyx does this and so much more. Take a look at Onyx's user reviews.